Methods for QTL analysis
نویسنده
چکیده
SINGLE VERSUS MULTIPLE MARKERS ........................................................................................................ 45 DETERMINING ASSOCIATIONS BETWEEN GENETIC MARKERS AND QTL WITH TWO MARKERS ................... 45 INTERVAL MAPPING .................................................................................................................................. 50 Maximum Likelihood........................................................................................................................... 50 REGRESSION METHODS ............................................................................................................................ 52 ANOVA analysis using single marker genotypes. ............................................................................... 52 ANOVA analysis using multiple marker genotypes. ............................................................................ 53 Regression on QTL probability, conditional on marker haplotypes.................................................... 53 Haley-Knott regression ....................................................................................................................... 57 Regression of phenotype on marker type............................................................................................. 58 MAXIMUM LIKELIHOOD ESTIMATION ....................................................................................................... 59 Example of simple QTL mapping with maximum likelihood ............................................................... 63 COMPARISON OF LIKELIHOOD AND REGRESSION PROCEDURES.................................................................. 67 THE GAMETIC RELATIONSHIP MATRIX APPROACH ................................................................................... 68
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